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“Femarelle treatment in postmenopausal women increases BMD without unwanted estrogenic effect.”

Tofupill/Femarelle (DT56a): a new phyto-selective estrogen receptor modulator- like substance for the treatment of postmenopausal bone loss.


After 12 months of treatment, BMD had increased in the study group by 3.6% in the lumbar
spine (P = 0.039) and by 2.0% in the femoral neck (NS). In the low-dose group, BMD had
decreased in the lumbar spine by 0.6% (NS) and by 0.6% in the femoral neck (NS).
Comparison of the change in bone density between the groups yielded a significant
difference for the lumbar spine (P = 0.037). Neither group showed a change in endometrial
thickness and sex hormone levels nor reported any side effects of treatment.

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